| Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea |
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Kyu Young Choi, Dong Young Kim |
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Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea. dongkim@snu.ac.kr |
| 우리나라 알레르기비염 환자에서 Dermatophagoides Pteronyssinus Der p 1, Der p 2, Der p 10 혈청 특이 IgE 분석 |
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최규영, 김동영 |
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서울대학교 의과대학 이비인후과학교실 |
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| Abstract |
Background and Objectives
To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles.
MATERIALS AND METHODS
Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250®. Symptom scores and laboratory findings were analyzed after SLIT.
Results
Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLITone○R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies.
Conclusion
In Korean AR patients, specific IgE antibodies to Der p 1 or Der p 2 are present in most Dp-allergic patients, while reactivity to Der p 10 is very low. Allergic symptoms improved in patients with Der p 10 IgE antibodies after SLIT. |
| Key Words:
Pyroglyphidae;Dermatophagoides pteronyssinus;Antigens, Dermatophagoides;Rhinitis, allergic;Sublingual immunotherapy |
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