Journal of Rhinology 2011;18(2):112-115.
Published online November 30, 2011.
Blood Level of Soluble CD30 and Soluble E-Selectin in Allergic Rhinitis Patients
Kyoung Ho Jun, Ha Min Jeong, Sang Heon Choi, Jae Hoon Lee
Department of Otolaryngology-Head & Neck Surgery, Institute of Wonkwang Medical Science, School of Medicine, Wonkwang University, Iksan, Korea.
알레르기비염 환자에서 혈액내 가용성 CD30과 E-Selectin 농도
전경호, 정하민, 최상헌, 이재훈
원광대학교 의과대학 이비인후과학교실
Background and Objectives
Blood levels of soluble CD30 and soluble E-selectin are related to allergic diseases such as atopic dermatitis or asthma. However, these levels have not been well investigated in allergic rhinitis. We evaluated the association of blood concentrations of these cytokines in allergic rhinitis.
Materials and Method
S: The concentrations of soluble CD30 and soluble E-selectin in blood were analyzed by enzyme linked immunosorbant assay. The levels of these cytokines were compared between allergic rhinitis patients (n=48) and age-matched healthy controls (n=27), and a relationship was found with symptom severity. RESULT: The concentration of soluble CD30 was significantly increased in allergic rhinitis patients compared to that in normal healthy people (p=0.042). However, soluble E-selectin was not significantly increased in allergic rhinitis patients (p>0.05).
These results suggest a possible role of soluble CD30 in the blood of allergic rhinitis.
Key Words: Allergic rhinitis;CD30;E-selectin

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