J Rhinol > Volume 22(1); 2015
Journal of Rhinology 2015;22(1):18-27.
Published online May 31, 2015.
DOI: https://doi.org/10.18787/jr.2015.22.1.18   
Clinical Characteristics and Expression Pattern of IL-33 and IL-25 According to Histologic Classification in Chronic Rhinosinusitis with Nasal Polyposis
Sung Ha Kim, Ji Hun Mo, Young Jun Chung, Jun Xu, Sung Jae Park, Ki Sang Rha, Yong Min Kim
1Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Korea. entkym@cnu.ac.kr
2Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University School of Medicine, Chonan, Korea.
비용의 조직학적 분류에 따른 만성 비부비동염의 임상적 특징과 IL-33과 IL-25의 발현
김성하, 모지훈, 정영준, 허준, 박성제, 나기상, 김용민
충남대학교 의학전문대학원 이비인후과학교실, 의학연구소,1 단국대학교 의과대학 이비인후과학교실2
Abstract
Background and Objectives
Many kinds of inflammatory cells and cytokines are suggested to be related to the pathophysiology of chronic rhinosinusitis with nasal polyposis (CRSwNP), but not yet fully understood. The objectives of this study were to classify CRSwNP patients according to histologic features and to reveal the roles of IL-33 and IL-25, on the pathophysiology of CRSwNP.
Materials and Method
CRSwNP patients (n=122) were divided into 3 groups according to the type of nasal polyp; eosinophilic polyp (EP, n=38), neutrophilic polyp (NeuP, n=15) and non-eosinophilic non-neutrophilic polyp (NENN, n=63) groups. Clinical features and the expressions of IL-25 and IL-33 were evaluated among the groups.
Results
The EP group showed many clinical features that were different from the other groups: increased prevalence of asthma and olfactory dysfunction, increased percentage of blood eosinophils, increased E/M ratio, and poor postoperative outcomes such as recurrent polyposis and the need for frequent use of oral steroids. Numbers of IL-33 and IL-25 positive cells were significantly higher in the EP group compared with the other groups in the lamina propria (p=0.001).
Conclusion
These results suggest that patients with an eosinophilic polyp are clinically and pathogenetically different from patients with other types of polyps, and IL-25 and IL-33 are associated with the pathogenesis of chronic rhinosinusitis with eosinophilic polyps.
Key Words: Nasal polyps;Sinusitis;Eosinophil;IL-25;IL-33


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