J Rhinol > Volume 23(1); 2016
Journal of Rhinology 2016;23(1):6-16.
Published online May 31, 2016.
DOI: https://doi.org/10.18787/jr.2016.23.1.6   
Efficacy and Safety of Newly Developed Korean Continuous Positive Airway Pressure Treatment in Patients with Obstructive Sleep Apnea Syndrome
Jong In Jeong, Jung Joo Lee, Seonwoo Kim, Su Jin Kim, Sang Duk Hong, Seung Kyu Chung, Hun Jong Dhong, Hojoong Kim, Hyo Yeol Kim
1Department of Otorhinolaryngology, School of Medicine, Keimyung University, Daegu, Korea.
2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul, Korea. hysiam.kim@samsung.com
3Biostatistics Unit, Samsung Biomedical Reserch Institute, Seoul, Korea.
4Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
폐쇄성 수면 무호흡증 환자에서 신형 국산 지속성 기도 양압기 치료의 유효성과 안전성
정종인, 이정주, 김선우, 김수진, 홍상덕, 정승규, 동헌종, 김호중, 김효열
계명대학교 의과대학 이비인후과학교실,1 성균관대학교 의과대학 삼성서울병원 이비인후과학교실,2 삼성생명과학연구소 통계지원팀,3 내과학교실 호흡기내과4
Abstract
Background and Objectives
Obstructive sleep apnea syndrome(OSAS) is characterized by repeated apnea, hypopnea, and micro-arousals during sleep. Among various treatment modalities of OSAS, continuous positive airway pressure(CPAP) treatment is the most effective and successful. The aim of this study was to compare efficacy and safety of newly developed Korean CPAP with standard CPAP in OSAS patients.
Materials and Method
In total, 20 of 26 recruited OSAS patients completed the study. All subjects first used the standard CPAP for 4 weeks. After an at least 2 week wash-out period, the subjects used the newly developed CPAP for 4 weeks. Polysomnography, questionnaires associated with sleep, lipid profile, pulmonary function test, cardiac marker, and physical examinations were evaluated at baseline and were followed-up after each treatment.
Results
After treatment with the newly developed CPAP, the apnea-hypopnea index was decreased from 53.2/hr to 2.5/hr and was equivalent to that of the standard CPAP. Most of the changes in questionnaire scores, laboratory findings, and physical examinations after newly developed CPAP treatment were equivalent to those with standard CPAP. No serious adverse events were observed during the study.
Conclusion
The efficacy and safety of a newly developed CPAP are equivalent to those of standard CPAP in OSAS patients.
Key Words: OSAS;AHI;Efficacy;Safety;Newly developed Korean CPAP




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