J Rhinol > Volume 23(1); 2016
Journal of Rhinology 2016;23(1):44-48.
Published online May 31, 2016.
DOI: https://doi.org/10.18787/jr.2016.23.1.44   
Three Cases of IgG4-Related Sclerosing Disease in Nasal Cavity
Jae Ryung Lee, Bong Jae Lee, Yoo Sam Chung
Department of Otoloaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. yschung@amc.seoul.kr
비강 내에 발생한 면역글로불린G4 연관 경화성 질환 3예
이재령, 이봉재, 정유삼
울산대학교 의과대학 서울아산병원 이비인후과학교실
Abstract
IgG4-related sclerosing disease (IgG4-RSD) is characterized by extensive IgG4-positive plasma cell and T-lymphocyte infiltration of various organs. However, the nasal cavity is an extremely rare site of involvement. The authors experienced three cases of igG4-RSD in the nasal cavity. A 54-year-old woman presented with a nasal cavity mass on endoscopic exam and computed tomography (CT) revealed not only a hypoenhancing mass in the right nasal cavity but also a pituitary gland macroadenoma. Endoscopic removal and endoscopic TSA were performed. A 20-year-old man diagnosed with chronic sinusitis, underwent endoscopic sinus surgery. A 26-year-old woman showed thickening of the nasal septum and cribriform plate, and an infiltrating soft tissue lesion in right the alveolar process on CT and an endoscopic biopsy was performed. Pathologic specimens of all cases showed IgG4-positive plasma cell infiltration, consistent with IgG4-RSD. Serum IgG4 levels were checked in two of the cases, and the results were within normal range. All cases were further treated with methylprednisolone and all showed clinical improvement.
Key Words: IgG4-related sclerosing disease




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