J Rhinol > Epub ahead of print
Published online January 15, 2021.
DOI: https://doi.org/10.18787/jr.2020.00337    [Epub ahead of print]
A Case of Atypical Central Skull Base Osteomyelitis with Bilateral Alveolar Bone Destruction
Sohl Park1, Ju Hyun Yun1, Su Jin Kim1, Jung Ho Bae2, So Jeong Kim1
1Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, School of Medicine, Mokdong Hospital, Seoul, Korea
2Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, School of Medicine, Seoul Hospital, Seoul, Korea
So Jeong Kim, Tel: +82-2-2650-5988, Fax: +82-2-2648-5604, Email: entsjkim@gmail.com
Received: 5 October 2020   • Revised: 7 December 2020   • Accepted: 10 December 2020
Central skull base osteomyelitis (CSBO) is a rare, fatal condition seen mostly in elderly diabetic or immunocompromised patients; it mainly involves the sphenoid or occipital bones and diagnosis is often delayed. A 72-year-old male with diabetes was referred to our department with severe pain in the maxillary gingiva. Endoscopic biopsy of the pterygoid bone confirmed the presence of mucormycosis combined with Klebsiella pneumoniae infection. Sinus surgery was performed with bilateral alveolar bone sequestrectomy. Long-term intravenous broad-spectrum antibiotic therapy using meropenem and ampicillin/sulbactam and antifungal therapy using amphotericin B (100 mg/day) was administered; an oral antifungal agent, posaconazole (800 mg/day), was also prescribed for 11 weeks. At the 6-month follow-up visit, there were no complications and no progression of the CSBO lesion was observed. Timely diagnosis and multidisciplinary treatment including endoscopic surgery, alveolar bone sequestrectomy, and combined antifungal and antibiotic therapy can reduce mortality and minimize complications associated with CSBO.
Key Words: Skull baseOsteomyelitisMucormycosisMaxillaAlveolar process

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