Pathogenesis of Nasal Polyps

Jang, Tae Young

Review

Journal of Rhinology 1999;6(1):5-11.
Published online May 31, 1999.

Pathogenesis of Nasal Polyps

Tae Young Jang

Department of Otolaryngology, College of Medicine, InHa University, Inchon, Korea.

Abstract

While polyposis in the nose and paranasal sinuses continues to be a major clinical problem, the pathogenesis of nasal polyps remains controversial. Many etiologic theories, including those pointing to allergy, have been suggested. Most of the recent studies on nasal polyps focus on two key areas: the molecular and cellular network of the inflammatory process and the mechanisms behind polyp growth. Inflammatory changes in nasal mucosa can increase the effector capabilities of structural cell-derived cytokines, and represent a major amplification pathway of the inflammatory response in nasal polyps. The resultant edema can lead to the growth of nasal polyps. The role of allergy in the pathogenesis of nasal polyps remains unclear, but allergy may be one mechanism driving the chain of events leading to inflammation.

Key Words: Nasal polyps;Pathogenesis;Allergic rhinitis;Cytokines