Journal of Rhinology 1999;6(2):91-98.
Published online November 30, 1999.
A Study of the Expression of Cytokines and p53 in Nasal Polyps
Myoung Sil Ju, Chong Nahm Kim, Young Sook Hong
1Department of Otolaryngology, College of Medicine, Ewha Womans University, Seoul, Korea.
2Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
Background and Objectives
Nasal polyps are a condition of uncertain etiology. Cytokines are thought to play a role in nasal polyps in vitro, but in vivo studies on the patterns of cytokine expression in nasal polyps have been limited. The aim of the present study is to gain a better understanding of the pathophysiology of nasal polyps by defining the patterns of expression of cytokine mRNA and p53 in the nasal mucosa of patients with nasal polyps.
Materials and Method
S: This objective was supported by performing RT-PCR (reverse transcription-polymerase chain reaction) for IL-2, INF-gamma (T1 cytokine), IL-5, IL-8, IL-10, IL-13 (T2 cytokine), TNF-alpha, TGF-beta1, and p53.
Results
Observation of the nasal polyps indicated significant increases in mRNA for T2 cytokines and p53 over controls. The expressions of IL-10 and IL-13 mRNA in the nasal mucosa of non-allergic patients were stronger than in that of allergic patients.
Conclusion
This result suggests that the pathogenesis of nasal polyps is associated with T2 cytokines and p53.
Key Words: Nasal;Polyp;Pathogenesis;Cytokine;p53




Editorial Office
101 Hyundai ESA Apt., 20, Hyoryeong-ro 77-gil, Seocho-gu, Seoul 06628, Republic of Korea
Tel: +82-2-3461-9945    Fax: +82-2-3461-9947    E-mail: shcho@hanyang.ac.kr                

Copyright © 2021 by Korean Rhinologic Society. All rights reserved.

Developed in M2PI

Close layer
prev next