Journal of Rhinology 2008;15(1):30-34.
Published online May 31, 2008.
A Comparison of Histopathologic Findings in the Nasal Polyp, Maxillary Sinus Mucosa, and Inferior Turbinate Mucosa
Gil Soo Han, In Seo Park, Dong Youl Lee, Chang Hyo Kim, Yoon Suk Oh, Tae Young Jang
1Department of Otorhinolaryngology-Head & Neck Surgery, Inha University, College of Medicine, Incheon, Korea.
2Department of Pathology, Inha University, College of Medicine, Incheon, Korea.
비용, 상악동 및 하비갑개 조직의 병리조직학적 소견의 비교
한길수, 박인서, 이동율, 김창효, 오윤석, 장태영
인하대학교 의과대학 이비인후-두경부외과학교실,1 병리과학교실2
Background and Objectives
The nasal polyp is the most common form of mass lesion in the nose with an unclear etiology and pathogenesis among patients in Asia. Also, the pathological characteristic of nasal polyps in these patients is eosinophil infiltration. These findings, as reported in Asia, are distinct from those of the West. Moreover, the role of eosinophil is recently found to be on the increase even in Asia. So, we investigated the proportion of eosinophil infiltration in the nasal polyp among patients in Korea.
Materials and Method
S: The study group consisted of 35 patients with a mean age of 43 years (ranging from 6 to 72 years). Tissue samples were taken via endoscopic sinus surgeries from the nasal polyp, inflammatory sinus mucosa, and the inferior turbinate. We compared 5 parameters of mucosal histopathology. RESULT: The incidence of a severe eosinophilic infiltration in the nasal polyp was 70%. Nasal polyp and inflammatory sinus mucosa had a larger eosinophil, lymphocyte and polymorphonuclear leukocyte infiltration than a normal nasal mucosa. Also, the nasal polyp and sinus mucosa had a more severe basement membrane thickening and goblet cell hyperplasia. Distinctively, the nasal polyp had a severe eosinophilic infiltration and a more thickened basement membrane.
The present histopathologic feature of the nasal polyp among Koreans indicates that cases of eosinophilic nasal polyp seems to be on the increase.
Key Words: Nasal polyp;Eosinophil infiltration;Mucosal histopathology

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