Journal of Rhinology 2008;15(2):108-114.
Published online November 30, 2008.
Expression of p53, p21, Cycin D1, and Ki-67 in Sinonasal Tumors
Ha Min Jeong, Jae Hoon Lee, Ki Jung Yun
1Department of Otolaryngology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
2Department of Pathology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea.
비강 및 부비동 종양에서의 p53, p21, Cyclin D1, Ki-67 발현
정하민, 이재훈, 윤기중
원광대학교 의과대학 이비인후과학교실,1 병리학교실2
Abstract
Background and Objectives
The goal of this study is to investigate alterations of cell-cycle-related molecules, including p53, p21, cyclin D1 and Ki-67, in tumors arising in the sinonasal region. MATERIALS AND METHODS: The study materials were 16 specimens of normal nasal mucosa, 16 inverted papillomas (IPs) and 12 sinonasal squamous cell carcinomas. The p53, p21, cyclin D1 and Ki-67 expression was assessed by immunohistochemical staining. RESULT: IP and squamous cell carcinoma showed significant increase in the expression of p53, cyclin D1 and Ki-67 than normal mucosa. The expression of p53, cyclin D1 and Ki-67 of the carcinoma was stronger than the IP. But, the p21 expression was not associated with the IP and carcinoma. CONCLUSION: Increased levels of p53, cyclin D1 and Ki-67 expression correlate with increased cell proliferation in the tumors of sinonasal regions. These findings indicate that p53, cyclin D1 and Ki-67 expression may be useful markers for the dysregulations of cell kinetics in the tumors of sinonasal region.
Key Words: Inverted papilloma;Sinonasal squamous cell carcinoma;p53;Cyclin D1;Ki-67




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