Journal of Rhinology 2010;17(1):7-12.
Published online May 31, 2010.
Genetic Role in Allergic Rhinitis
Jae Hoon Lee, Seung Hyun Koh
Department of Otolaryngology-Head and Neck Surgery, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea. nose-1023@hanmail.net
알레르기비염에서의 유전적 역할
이재훈, 고승현
원광대학교 의과대학 이비인후-두경부외과학교실
Abstract
Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by an IgE-mediated reaction following exposure to an allergen. Allergic rhinitis is a global health problem, with a prevalence of between 9-42% among the general population. While it is known that allergic rhinitis does not exhibit a Mendelian hereditary pattern, the disease does have a hereditary component. The development of allergic rhinitis entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. Genetic studies about several atopic diseases, including allergic rhinitis, are now actively in progress, but most of the studies focus on asthma and adverse drug reactions. Current genetic studies of allergic rhinitis include family and twin studies, genome-wide linkage analyses, and candidate gene association studies. Also ongoing are studies to identify susceptibility genes and to understand factors influencing gene expression.
Key Words: Allergic rhinitis;Genetic;Multifactorial




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