Journal of Rhinology 2010;17(2):92-96.
Published online November 30, 2010.
Response of Peripheral Blood Mononuclear Cells to Staphylococcus Aureus Exotoxin in Nasal Polyposis
Se Hwan Hwang, Byung Guk Kim, Soo Whan Kim, Jin Hee Cho, Ji Hyeon Shin, Jun Myung Kang
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Buchon, Korea.
비용종 환자에서 포도상구균 외독소에 대한 말초혈액 단핵구의 반응
황세환, 김병국, 김수환, 조진희, 신지현, 강준명
가톨릭대학교 의과대학 이비인후과학교실
Background and Objectives
Superantigens such as Staphylococcus aureus exotoxin (SE) have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (NP). The aim of this study was to determine the immunologic response of peripheral blood mononuclear cells (PBMCs) to staphylococcal exotoxin B (SEB) in patients with NP.
The interleukin (IL)-4, IL-5, and interferon-gamma(IFN-gamma) responses of PBMCs to nonspecific mitogens such as phylohemagglutin (PHA) and SEB were examined in 24 NP patients and 16 control subjects. The presence or absence of atopy and asthma was determined to evaluate the correlation of these conditions with the levels of cytokines.
PBMCs from the NP patients were more likely to produce IL-4 and IL-5 in response to SEB than those from controls. There was no difference in the mitogen-induced cytokine responses between NP patients and controls. SEB-induced IL-5 and IL-4 levels were higher in patients with NP with asthma than in patients with NP without asthma.
Patients with NP show an exaggerated Th2 cytokine response of PBMCs to SEB.
Key Words: Nasal polyposis;Staphylococcus aureus exotoxin;Peripheral blood mononuclear cell

METRICS Graph View
  • 686 View
  • 2 Download
Related articles

Editorial Office
101 Hyundai ESA Apt., 20, Hyoryeong-ro 77-gil, Seocho-gu, Seoul 06628, Republic of Korea
Tel: +82-2-3461-9945    Fax: +82-2-3461-9947    E-mail:                

Copyright © 2023 by Korean Rhinologic Society.

Developed in M2PI

Close layer
prev next