J Rhinol > Volume 26(1); 2019
Journal of Rhinology 2019;26(1):1-7.
Published online May 31, 2019.
DOI: https://doi.org/10.18787/jr.2019.26.1.1   
Neurogenesis and Regulation of Olfactory Epithelium
Ji Sun Kim, Byung Guk Kim
Department of Otorhinolaryngology-Head and Neck Surgery, Eunpyeong St. Mar's, College of Medicine, The Catholic University of Korea, Seoul, Korea. entkbg@gmail.com
비후각 상피의 신경 생성과 조절
김지선김병국,
가톨릭대학교 의과대학 은평성모병원 이비인후과학교실
Abstract
The olfactory epithelium is capable of structural and functional recovery after injury through neurogenesis. Neurogenesis occurs via stem cells in the olfactory epithelium. Horizontal basal cells and globose basal cells in the basal layer of the epithelium have the characteristics of stem cells and progenitor cells of olfactory neurons. In order for the horizontal basal cells and globose basal cells to differentiate into olfactory neurons, distinct transcriptional factors are required at each stage. These transcription factors inhibit or synergize with each other or cells at each differentiation stage, regulating olfactory neurogenesis. Recently, the regulation of neurogenesis and development through epigenetic controls that change gene expression without changing the gene sequence have been studied. Studies of olfactory epithelium have helped to elucidate complex neurological systems including spinal cord and brain. In particular, features of neurogenesis will lead to medical advances in the treatment of central nervous diseases, which until this time have been considered impossible.
Key Words: Neurogenesis;Olfactory epithelium;Olfactory neural stem cell;Basal cell;Transcription factor


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