Journal of Rhinology 2013;20(1):20-25.
Published online May 31, 2013.
Therapeutic Effect of Combination Treatment of Antihistamine and Montelukast in Allergic Rhinitis
Hye Ran Son, Ki Il Lee, Young Jun Chung, Ji Hun Mo
1Department of Otorhinolaryngology-Head & Neck Surgery, Dankook University, College of Medicine, Cheonan, Korea. jihunmo@gmail.com
2Department of Otorhinolaryngology-Head & Neck Surgery, Kepco medical center, Seoul, Korea.
알레르기비염에서 항히스타민제와 Montelukast 복합요법의 효과
손혜란, 이기일, 정영준, 모지훈
단국대학교 의과대학 이비인후과학 교실1, 한전병원 이비인후과2
Abstract
BACKGROUND: Montelukast is a type 1 cysteinyl-leukotrienes receptor antagonist that has been widely used in allergic disease. However, the effect of combination of leukotriene receptor antagonist and antihistamine is controversial. The aim of this study was to compare the effect of combination treatment of montelukast and antihistamine, fexofenadine, over antihistamine alone in patients with allergic rhinitis (AR).
SUBJECTS AND METHOD
S: Retrospective chart review of 60 patients with AR was undertaken. Patients were classified into combination group (montelukast and fexofenadine, n=28) and antihistamine only group (fexofenadine, n=32) according to treatment modalities. Questionnaire survey was performed and allergic symptoms (VAS scale, 5pointscale), and SNOT (sinonasal outcome test)-20 score were obtained before and after the treatment.
Results
Mean follow-up duration was 6.7+/-4.6weeks. There was no significant difference in demographic data between two groups. Allergic symptoms and SNOT-20 score(nasal, QOL domain) were improved significantly in both groups after the treatment (all p < 0.001). Combination treatment group showed better improvement in nasal obstruction than antihistamine treatment group(p = 0.03). However, there were no significant differences in other allergic symptoms (rhinorrhea and sneezing) and SNOT-20 between two groups (all p > 0.05, respectively).
Conclusion
A combination treatment of montelukast and fexofenadine showed more efficacies in nasal obstruction than single fexofenadine treatment in patients with AR. Therefore, montelukast could be used effectively with antihistamine in patients with AR complaining nasal congestion.
Key Words: Allergic Rhinitis;Leukotriene Receptor Antagonist;Montelukast;Combination Therapy




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