J Rhinol > Volume 22(2); 2015
Journal of Rhinology 2015;22(2):75-81.
Published online November 30, 2015.
DOI: https://doi.org/10.18787/jr.2015.22.2.75   
Differences of Short-Term Systemic Responses in Obstructive Sleep Apnea Patient by Compliance of Continuous Positive Airway Pressure
Jong In Jeong, Su Jin Kim, Sang Duk Hong, Seung Kyu Chung, Hun Jong Dhong, Hyo Yeol Kim
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. siamkhy@gmail.com
폐쇄성 수면무호흡 환자에서 지속성 기도양압술 치료의 순응도에 따른 단기 전신 반응의 차이
정종인, 김수진, 홍상덕, 정승규, 동헌종, 김효열
성균관대학교 의과대학 삼성서울병원 이비인후과학교실
BACKGROUND: Obstructive sleep apnea (OSA) is characterized by repeated apnea, hypopnea, and micro-arousals during sleep. Many studies have described correlations between OSA and multiple systemic diseases, such as cardiovascular, cerebrovascular, and metabolic diseases. The aim of this study was to determine whether the compliance of continuous positive airway pressure (CPAP) affects the short-term systemic responses in OSA patients.
Twenty-four newly diagnosed OSA patients were enrolled. All subjects used CPAP for 4 weeks. The subjects were divided into two groups according to the rate of using CPAP over 4 hours per night. Complete blood cell count, coagulation results, blood chemistry, lipid profiles, and pulmonary function results were evaluated at baseline, and were followed up after 4 weeks.
After CPAP treatment, WBC count, hemoglobin, hematocrit, albumin, AST, ALT, Cl, and peak expiratory flow rate (PEFR) were significantly changed in the higher compliance group (n=14), whereas platelet count and triglyceride levels were significantly changed in the lower compliance group (n=10). In multivariate analysis, the changes in WBC count, hemoglobin and hematocrit were statistically significant between the higher compliance and lower compliance groups (p=0.0056, 0.0016, and 0.0051).
The compliance of CPAP affects the short-term systemic responses in OSA patient.
Key Words: OSA;CPAP;Intermittent hypoxia;Oxidative stress;Compliance of CPAP

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